Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 6/20 | 0.56 |
| ▸ | HTR2A | P28223 | 5/20 | 0.56 |
| ▸ | HTR7 | P34969 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304063 | 0.95 | ADRA1D (0.64) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296056 | 0.91 | ADRA1D (0.48) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296911 | 0.89 | ADRA1D (0.55) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8299591 | 0.88 | OPRM1 (0.56) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL27492957 | 0.87 | ADRA1D (0.53) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296768 | 0.86 | HSD11B1 (0.48) | DRD2HTR2AHTR7KCNH2SLC6A4 | |
| SCHEMBL8303699 | 0.82 | ADRA1D (0.57) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL27524757 | 0.81 | HTR1D (0.49) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296250 | 0.81 | HSD11B1 (0.62) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8435995 | 0.80 | ADRA1D (0.46) | ADRA1DDRD2HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |