Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.57 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299874 | 0.94 | OPRM1 (0.50) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8296717 | 0.89 | HTR1A (0.56) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8304063 | 0.87 | ADRA1D (0.64) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8297500 | 0.85 | HTR1A (0.53) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8302784 | 0.85 | HTR7 (0.56) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8303547 | 0.84 | DRD2 (0.51) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8298191 | 0.82 | HTR1A (0.56) | ADRA1DHTR2AHTR7ADRA1BHTR1A | |
| SCHEMBL8303406 | 0.82 | ADRA1D (0.58) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8296764 | 0.81 | HTR2A (0.52) | ADRA1DHTR2AHTR7DRD2KCNH2 | |
| SCHEMBL8299591 | 0.80 | OPRM1 (0.56) | ADRA1DHTR2AHTR7DRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |