Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | HTR1B | P28222 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8296768 | 0.96 | HSD11B1 (0.48) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL27492957 | 0.94 | ADRA1D (0.53) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8299591 | 0.91 | OPRM1 (0.56) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8296056 | 0.90 | ADRA1D (0.48) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8301506 | 0.86 | HSD11B1 (0.51) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8304063 | 0.86 | ADRA1D (0.64) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8435995 | 0.85 | ADRA1D (0.46) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8575896 | 0.83 | ADRA1D (0.50) | HTR1DSLC6A4HTR1BDRD2CHRM2 | |
| SCHEMBL8303406 | 0.81 | ADRA1D (0.58) | HTR1DSLC6A4HTR1BDRD2ADRA1D | |
| SCHEMBL8303863 | 0.81 | RORC (0.48) | SLC6A4DRD2OPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |