Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 10/20 | 0.53 |
| ▸ | MAOB | P27338 | 10/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7891254 | 0.88 | PBRM1 (0.59) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL8131108 | 0.84 | MAOA (0.61) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL5543621 | 0.78 | MAOA (0.55) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL8870788 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL1274936 | 0.76 | MAOA (0.59) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL385554 | 0.76 | PBRM1 (0.78) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL769238 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL3665755 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL656011 | 0.76 | CASP1 (0.55) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL29446042 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008039520-A2 | FUSED RING COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2004094413-A1 | PHENACYL 2-HYDROXY-3-DIAMINOALKANES | ELAN PHARMACEUTICALS, INC. (US) | 2004-11-04 | — | — | WO | disclosed |
| WO-2004094384-A2 | (HETERO) ARYLAMIDE 2-HYDROXY-3-DIAMINOALKANES FOR USE IN THE TREATMENT OF ALZHEIMER’S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2004-11-04 | — | — | WO | disclosed |