Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 10/20 | 0.53 |
| ▸ | MAOB | P27338 | 10/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | PRKCI | P41743 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871212 | 0.88 | PBRM1 (0.59) | MAOAMAOBCYP2A6MEN1KMT2A | |
| SCHEMBL5858951 | 0.84 | MAOA (0.61) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL5543621 | 0.78 | MAOA (0.55) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL1274936 | 0.76 | MAOA (0.59) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL385554 | 0.76 | PBRM1 (0.78) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL3665755 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL769238 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL8303576 | 0.76 | MAOA (0.53) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL656011 | 0.76 | CASP1 (0.55) | MAOAMAOBCYP2A6PRKCIMEN1 | |
| SCHEMBL29673118 | 0.76 | MAOA (0.59) | MAOAMAOBCYP2A6PRKCIMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607928-A | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives | ZENECA LIMITED (GB) | 1997-03-04 | — | — | US | disclosed |
| EP-0695753-A1 | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use | ZENECA LIMITED (GB) | 1996-02-07 | — | — | EP | disclosed |