Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301928 | 0.84 | DRD2 (0.34) | DRD2HTR1AAR | |
| SCHEMBL8307985 | 0.83 | DRD2 (0.34) | DRD2HTR1A | |
| SCHEMBL8306164 | 0.81 | DRD2 (0.33) | DRD2HTR1A | |
| SCHEMBL8301874 | 0.80 | DRD2 (0.37) | DRD2HTR1AAR | |
| SCHEMBL8303552 | 0.79 | DRD2 (0.33) | DRD2HTR1A | |
| SCHEMBL8303888 | 0.78 | ADRA2A (0.42) | ALDH1A1GAAMAPTHSD17B10 | |
| SCHEMBL10027765 | 0.74 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTHSD17B10DRD2 | |
| SCHEMBL8308098 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTHSD17B10AR | |
| SCHEMBL8307056 | 0.73 | ALDH1A1 (0.43) | ALDH1A1GAAMAPTHSD17B10AR | |
| SCHEMBL8307073 | 0.69 | CYP11B1 (0.32) | ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| EP-0548254-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1993-06-30 | — | — | EP | disclosed |
| WO-1992004345-A1 | 6- or 7- (2-IMINO-2-IMIDAZOLIDINE)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN, INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |