Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303199 | 0.94 | HTR1A (0.43) | ALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL8303555 | 0.93 | HTR1A (0.47) | ALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL8306494 | 0.89 | ALDH1A1 (0.52) | ALDH1A1HTR1ADRD2 | |
| SCHEMBL8302093 | 0.83 | ALDH1A1 (0.39) | ALDH1A1HTR1ADRD2 | |
| SCHEMBL8304635 | 0.82 | DRD4 (0.43) | ALDH1A1HTR1ADRD2 | |
| SCHEMBL8307032 | 0.80 | HRH3 (0.50) | HTR1ADRD2HTR2ASIGMAR1 | |
| SCHEMBL8303876 | 0.79 | HTR1A (0.61) | HTR1ADRD2 | |
| SCHEMBL8303443 | 0.79 | HTR1A (0.58) | HTR1ADRD2MEN1KMT2ASIGMAR1 | |
| SCHEMBL9143190 | 0.77 | DRD2 (0.47) | HTR1ADRD2HTR2A | |
| SCHEMBL8303187 | 0.76 | DRD2 (0.37) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | claimed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | claimed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | claimed |
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |