Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303187 | 0.82 | DRD2 (0.37) | DRD2HTR1A | |
| SCHEMBL8303869 | 0.82 | ALDH1A1 (0.40) | DRD2ALDH1A1HTR1A | |
| SCHEMBL9143190 | 0.79 | DRD2 (0.47) | DRD4DRD3DRD2HTR1A | |
| SCHEMBL8303199 | 0.78 | HTR1A (0.43) | DRD2ALDH1A1HTR1A | |
| SCHEMBL8303443 | 0.78 | HTR1A (0.58) | DRD2POLBHTR1A | |
| SCHEMBL8304288 | 0.78 | ADRA1D (0.49) | DRD4DRD3DRD2HTR1A | |
| SCHEMBL8304638 | 0.78 | HTR1A (0.61) | DRD2HTR1A | |
| SCHEMBL8303555 | 0.78 | HTR1A (0.47) | DRD2ALDH1A1HTR1A | |
| SCHEMBL8307032 | 0.77 | HRH3 (0.50) | DRD2HTR1A | |
| SCHEMBL9179337 | 0.76 | DRD2 (0.43) | DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |