Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305318 | 0.80 | MAPT (0.57) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL8521515 | 0.78 | MEN1 (0.60) | POLBSMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL28092071 | 0.78 | MAPT (0.67) | POLBSMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL2306801 | 0.77 | MAPT (0.56) | POLBSMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL8305753 | 0.77 | SMN1; SMN2 (0.74) | POLBSMN1; SMN2RAB9ANPC1GAA | |
| SCHEMBL8307686 | 0.77 | ALOX5 (0.68) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL1454743 | 0.76 | MAPT (0.70) | SMN1; SMN2RAB9AALDH1A1MAPTLMNA | |
| SCHEMBL8308004 | 0.76 | MEN1 (0.69) | SMN1; SMN2GAAALDH1A1MAPTMEN1 | |
| SCHEMBL8306313 | 0.75 | AKR1C2 (0.65) | POLBSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL4728442 | 0.75 | NPC1 (0.58) | POLBSMN1; SMN2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |