Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 2/20 | 0.50 |
| ▸ | MC1R | Q01726 | 2/20 | 0.50 |
| ▸ | MC3R | P41968 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304059 | 1.00 | HTR2C (0.55) | HTR2CHTR2BGID4P2RX7MC4R | |
| SCHEMBL18019717 | 0.82 | PKM (0.57) | HTR2CHTR2BGID4P2RX7 | |
| SCHEMBL7996653 | 0.82 | GID4 (0.72) | HTR2CHTR2BGID4P2RX7KDM4E | |
| SCHEMBL7996650 | 0.82 | GID4 (0.72) | HTR2CHTR2BGID4P2RX7KDM4E | |
| SCHEMBL30946666 | 0.81 | P2RX7 (0.52) | HTR2BP2RX7MC4RMC1RMC3R | |
| SCHEMBL7874030 | 0.81 | HTR2C (0.77) | HTR2CHTR2BGID4MC4RKDM4E | |
| SCHEMBL5154669 | 0.81 | HTR2C (0.77) | HTR2CHTR2BGID4MC4RKDM4E | |
| SCHEMBL1789145 | 0.81 | HTR2C (0.77) | HTR2CHTR2BGID4MC4RKDM4E | |
| Hydrochloric Acid SCHEMBL7607289 | 0.80 | HTR2C (0.75) | HTR2CHTR2BGID4MC4RKDM4E | |
| Hydrochloric Acid SCHEMBL18337901 | 0.80 | HTR2C (0.75) | HTR2CHTR2BGID4MC4RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972984-A | LOW MOLECULAR WEIGHT PEPTIDYL COMPOUNDS THAT DO NOT HAVE A THIOL MOIETY. | MERCK & CO., INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0833633-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5756528-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0833633-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996039137-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-12-12 | — | — | WO | disclosed |