Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | POLH | Q9Y253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307532 | 0.98 | L3MBTL1 (0.39) | BRD4ABCB1MAOBMAOAKDM4E | |
| SCHEMBL8306914 | 0.95 | CYP1B1 (0.43) | ABCB1MAOBMAOAMEN1ALDH1A1 | |
| SCHEMBL8307688 | 0.92 | MAPT (0.35) | BRD4MAOBMAOAKDM4EMEN1 | |
| SCHEMBL8306597 | 0.91 | ABCB1 (0.42) | BRD4ABCB1MAOBMAOAKDM4E | |
| SCHEMBL8310185 | 0.90 | MAOB (0.41) | BRD4ABCB1MAOBMAOAKDM4E | |
| SCHEMBL8309735 | 0.89 | KDM4E (0.39) | ABCB1KDM4EABCG2POLHPOLB | |
| SCHEMBL8308992 | 0.88 | MAOB (0.39) | BRD4ABCB1MAOBMAOAKDM4E | |
| SCHEMBL8306988 | 0.85 | CYP1B1 (0.42) | ABCB1MAOBMAOAMEN1ALDH1A1 | |
| SCHEMBL8431005 | 0.84 | HPGD (0.50) | BRD4KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL8427269 | 0.82 | EGFR (0.43) | KDM4EALDH1A1POLBMAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |