Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | IPMK | Q8NFU5 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304673 | 0.95 | BRD4 (0.40) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 | |
| SCHEMBL8307532 | 0.94 | L3MBTL1 (0.39) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 | |
| SCHEMBL8306988 | 0.90 | CYP1B1 (0.42) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 | |
| SCHEMBL8309735 | 0.89 | KDM4E (0.39) | CYP1B1CYP1A1CYP1A2KDRFLT3 | |
| SCHEMBL8307688 | 0.89 | MAPT (0.35) | MAOAPPARGMAOBMAPTMEN1 | |
| SCHEMBL8427269 | 0.87 | EGFR (0.43) | CYP1A2EGFRRETKDRPPARG | |
| SCHEMBL8306597 | 0.86 | ABCB1 (0.42) | MAOAPPARGMAOBQPCTABCB1 | |
| SCHEMBL8310185 | 0.85 | MAOB (0.41) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 | |
| SCHEMBL8572731 | 0.85 | QPCT (0.38) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 | |
| SCHEMBL8308992 | 0.85 | MAOB (0.39) | CYP1B1IP6K2CYP1A1CYP1A2ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0803503-B1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR (FR) | 1999-11-03 | — | — | EP | disclosed |
| US-5792789-A | TREATING HYPERPERMEABILITY AND INFLAMMATION | ADIR ET COMPAGNIE (FR) | 1998-08-11 | — | — | US | disclosed |
| EP-0803503-A1 | Acids and esters of diosmetin and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-10-29 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |