Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.42 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308082 | 0.89 | CYP4F2 (0.41) | TBXAS1CYP4F2CYP4A11TAAR1MAPT | |
| SCHEMBL8705235 | 0.87 | CYP4F2 (0.37) | TBXAS1CYP4F2CYP4A11TAAR1MAPT | |
| SCHEMBL11487887 | 0.85 | TAAR1 (0.48) | CYP4F2CYP4A11TAAR1MAPTPDE3B | |
| SCHEMBL11474938 | 0.85 | CYP4F2 (0.56) | TBXAS1CYP4F2CYP4A11TAAR1MAPT | |
| SCHEMBL3591993 | 0.81 | MAPT (0.52) | TBXAS1CYP4F2CYP4A11TAAR1MAPT | |
| SCHEMBL8304916 | 0.81 | PDE3B (0.36) | CYP4F2CYP4A11MAPTPDE3BPDE3A | |
| SCHEMBL11475112 | 0.79 | ALOX5 (0.51) | CYP4F2CYP4A11TAAR1MAPTCYP4Z1 | |
| SCHEMBL8310260 | 0.79 | TBXAS1 (0.50) | TBXAS1CYP4F2CYP4A11MAPTCYP4Z1 | |
| SCHEMBL11477432 | 0.78 | ALOX5 (0.52) | TBXAS1CYP4F2CYP4A11TAAR1MAPT | |
| SCHEMBL11477606 | 0.77 | TAAR1 (0.60) | TBXAS1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |