Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309155 | 0.83 | CYP17A1 (0.47) | CA1CA2KDM4EPOLBMAPT | |
| SCHEMBL8304739 | 0.81 | TBXAS1 (0.46) | PDE3BPDE3AP2RY12KDM4EMAPT | |
| SCHEMBL8308082 | 0.80 | CYP4F2 (0.41) | PDE3BPDE3AP2RY12KDM4EMAPT | |
| SCHEMBL8307372 | 0.80 | TBXAS1 (0.53) | ALDH1A1 | |
| SCHEMBL8592476 | 0.79 | HPGD (0.42) | CA1CA2POLBMAPTCYP4F2 | |
| SCHEMBL4495406 | 0.78 | CYP4F2 (0.56) | CA1CA2MAPTCYP4F2CYP4A11 | |
| SCHEMBL4713820 | 0.78 | NPSR1 (0.47) | NPSR1ALDH1A1GFERTDP1HTT | |
| SCHEMBL11487887 | 0.77 | TAAR1 (0.48) | PDE3BPDE3AP2RY12KDM4EMAPT | |
| SCHEMBL8308674 | 0.76 | TBXAS1 (0.49) | CA1CA2ALDH1A1GLAKMT2A | |
| SCHEMBL11474938 | 0.76 | CYP4F2 (0.56) | PDE3BPDE3AP2RY12KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |