Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.45 |
| ▸ | NAMPT | P43490 | 3/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.41 |
| ▸ | CYP21A2 | P08686 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304735 | 0.81 | TBXAS1 (0.61) | TBXAS1NAMPTCYP11B1ALDH1A1ABL1 | |
| SCHEMBL8307497 | 0.80 | ALDH1A1 (0.47) | TBXAS1NAMPTAGTR2CYP11B1CYP17A1 | |
| SCHEMBL8309155 | 0.80 | CYP17A1 (0.47) | TBXAS1NAMPTCYP17A1CYP3A4 | |
| SCHEMBL8705229 | 0.78 | ALDH1A1 (0.45) | TBXAS1NAMPTAGTR2CYP11B1ALDH1A1 | |
| SCHEMBL4495406 | 0.78 | CYP4F2 (0.56) | NAMPT | |
| SCHEMBL11487884 | 0.77 | CYP11B1 (0.56) | TBXAS1CYP11B1ALDH1A1ABL1RIN1 | |
| SCHEMBL8307372 | 0.77 | TBXAS1 (0.53) | TBXAS1CYP3A4ALDH1A1 | |
| SCHEMBL8304690 | 0.77 | TBXAS1 (0.78) | TBXAS1NAMPTAGTR2ALDH1A1 | |
| SCHEMBL11474932 | 0.77 | TBXAS1 (0.67) | TBXAS1CYP11B1CYP3A4ALDH1A1ABL1 | |
| SCHEMBL8705232 | 0.76 | TBXAS1 (0.46) | TBXAS1NAMPTAGTR2CYP11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |