SCHEMBL8305945

SCHEMBL8305945

COC(=O)C1CN=C(N)NC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.64
GABRR1 P24046 3/20 0.64
GABRA5 P31644 3/20 0.64
GABRB2 P47870 3/20 0.64
GABRA4 P48169 3/20 0.64
GABRP O00591 2/20 0.64
GABRD O14764 2/20 0.64
GABRB1 P18505 2/20 0.64
GABRG2 P18507 2/20 0.64
GABRB3 P28472 2/20 0.64
GABRA3 P34903 2/20 0.64
GABRA2 P47869 2/20 0.64
GABRE P78334 2/20 0.64
GABRA6 Q16445 2/20 0.64
GABRG1 Q8N1C3 2/20 0.64
GABRG3 Q99928 2/20 0.64
GABRQ Q9UN88 2/20 0.64
CHRNB2 P17787 2/20 0.41
CHRNA4 P43681 2/20 0.41
CHRNB4 P30926 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8622201 0.98 GABRA1 (0.62) GABRA1GABRR1GABRA5GABRB2GABRA4
SCHEMBL8914146 0.76 GABRA1 (0.58) GABRA1GABRR1GABRA5GABRB2GABRA4
Hydrochloric Acid SCHEMBL8914604 0.74 GABRA1 (0.57) GABRA1GABRR1GABRA5GABRB2GABRA4
SCHEMBL8309304 0.70 GABRP (0.62) GABRA1GABRR1GABRA5GABRB2GABRA4
SCHEMBL8590045 0.69 ALDH1A1 (0.36) GABRA1GABRR1GABRA5GABRB2GABRA4
Hydrochloric Acid SCHEMBL8306735 0.69 GABRP (0.61) GABRA1GABRR1GABRA5GABRB2GABRA4
SCHEMBL1026647 0.67 BRD4 (0.46) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL22279768 0.67 BRD4 (0.46) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL28009406 0.67 BRD4 (0.46) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL6937734 0.66 CHRNB2 (0.47) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0630244-B1 MUSCARINIC AGONISTS UNIV TOLEDO (US) 1999-12-01 EP claimed