Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8307230 | 0.99 | CTSD (0.46) | CTSDNPC1LMNAALOX15HSD17B10 | |
| SCHEMBL8441148 | 0.81 | GABRP (0.48) | NPC1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL9122774 | 0.80 | HDAC1 (0.43) | CTSDNPC1LMNAHDAC1KMT2A | |
| Bromide SCHEMBL8305746 | 0.80 | CES2 (0.37) | NPC1ALOX15KMT2AMEN1HPGD | |
| Hydrochloric Acid SCHEMBL8304040 | 0.80 | GABRP (0.47) | NPC1LMNAHSD17B10KMT2AMEN1 | |
| Bromide SCHEMBL10365922 | 0.80 | CES2 (0.37) | NPC1ALOX15KMT2AMEN1HPGD | |
| Bromide SCHEMBL8305743 | 0.80 | CES2 (0.37) | NPC1ALOX15KMT2AMEN1HPGD | |
| Bromide SCHEMBL10367565 | 0.80 | GABRP (0.47) | NPC1LMNAHSD17B10KMT2AMEN1 | |
| SCHEMBL8304637 | 0.79 | NPC1 (0.48) | NPC1LMNAALOX15KMT2AMEN1 | |
| SCHEMBL8308215 | 0.78 | LMNA (0.41) | LMNAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0582182-B1 | 1-Aminoacetamidopyrroles and 1-amino-2-(substituted) pyrroles and their use for the treatment of neurodegenerative dysfunctions | HOECHST MARION ROUSSEL INC (US) | 1999-10-20 | — | — | EP | claimed |
| US-5428053-A | Treats alzheimer's disease and other senile dementias | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | claimed |