Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | NPY1R | P25929 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308398 | 0.88 | KMT2A (0.37) | KDM4EALDH1A1MAOB | |
| SCHEMBL8306856 | 0.87 | KDM4E (0.43) | KDM4EALDH1A1 | |
| SCHEMBL8310235 | 0.84 | GRIN2B (0.49) | GRIN2B | |
| SCHEMBL8309546 | 0.81 | FYN (0.47) | GRIN2B | |
| SCHEMBL8307046 | 0.77 | KDM1A (0.48) | KDM4EGRIN2BALDH1A1MAOB | |
| SCHEMBL8305839 | 0.77 | GRIN2B (0.38) | GRIN2B | |
| SCHEMBL8309243 | 0.76 | MTTP (0.45) | — | |
| SCHEMBL8177517 | 0.76 | ACKR3 (0.40) | KDM4EGRIN2BALDH1A1LMNAMAOB | |
| SCHEMBL8309227 | 0.75 | DRD2 (0.40) | GRIN2BLMNA | |
| SCHEMBL8306217 | 0.74 | SMO (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759027-B1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AB (SE) | 1999-08-04 | — | — | EP | claimed |