Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306747 | 0.87 | KDM4E (0.36) | KDM4EALDH1A1 | |
| SCHEMBL8310235 | 0.80 | GRIN2B (0.49) | NPC1RAB9A | |
| SCHEMBL8309546 | 0.80 | FYN (0.47) | NPC1RAB9A | |
| SCHEMBL8310121 | 0.79 | ACHE (0.38) | CTSSNPC1KMT2A | |
| SCHEMBL8187982 | 0.77 | KDM4E (0.42) | KDM4EKCNA5CTSSALDH1A1PRMT5 | |
| SCHEMBL8308398 | 0.75 | KMT2A (0.37) | KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL8309243 | 0.75 | MTTP (0.45) | RAB9AKMT2AMEN1 | |
| SCHEMBL8308422 | 0.75 | ACHE (0.36) | — | |
| SCHEMBL6555243 | 0.72 | TAS2R38 (0.38) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7510363 | 0.72 | CNR1 (0.41) | CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0759027-B1 | BICYCLIC AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHETASE | ASTRA AB (SE) | 1999-08-04 | — | — | EP | claimed |