Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 12/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304728 | 0.88 | TBXAS1 (0.77) | TBXAS1TSHR | |
| SCHEMBL8309257 | 0.86 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8306769 | 0.84 | TBXAS1 (0.63) | TBXAS1MEN1KMT2ATSHRPKM | |
| SCHEMBL8307025 | 0.82 | TBXAS1 (0.75) | TBXAS1MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL8309319 | 0.82 | TBXAS1 (0.59) | TBXAS1MEN1KMT2AMAPK1HTT | |
| SCHEMBL8310260 | 0.80 | TBXAS1 (0.50) | TBXAS1CYP4F2CYP4A11NAMPT | |
| SCHEMBL8310097 | 0.79 | TBXAS1 (0.79) | TBXAS1TSHR | |
| SCHEMBL8308006 | 0.79 | CYP4F2 (0.47) | TBXAS1MEN1KMT2ATSHRCYP4F2 | |
| SCHEMBL8309155 | 0.77 | CYP17A1 (0.47) | TBXAS1KMT2ACYP4F2CYP4A11NAMPT | |
| SCHEMBL8310249 | 0.76 | TBXAS1 (0.62) | TBXAS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |