Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447241 | 0.81 | KCNN4 (0.43) | KCNN4HSD11B1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL7647188 | 0.79 | POLB (0.41) | KCNN4NPC1RAB9AALDH1A1POLB | |
| SCHEMBL7353764 | 0.78 | KCNN4 (0.54) | KCNN4HSD11B1ALDH1A1POLBMEN1 | |
| SCHEMBL7443610 | 0.78 | NPSR1 (0.38) | NPC1ALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL7670834 | 0.76 | AGTR1 (0.39) | ALDH1A1SMN1; SMN2LMNANPSR1MEN1 | |
| SCHEMBL4408728 | 0.75 | ALDH1A1 (0.50) | HSD11B1ALDH1A1POLBSMN1; SMN2LMNA | |
| SCHEMBL8539617 | 0.73 | KCNN4 (0.44) | KCNN4HSD11B1SLC6A2SLC6A4NPC1 | |
| SCHEMBL6671874 | 0.69 | NPSR1 (0.34) | ALDH1A1POLBSMN1; SMN2LMNANPSR1 | |
| SCHEMBL9139454 | 0.68 | KCNN4 (0.52) | KCNN4HSD11B1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL5813523 | 0.68 | P2RX7 (0.65) | SLC6A2SLC6A4ALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965738-A | Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0782996-B1 | PROCESS FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVE OR SALT THEREOF AND INTERMEDIATE FOR PRODUCING THE SAME | WAKUNAGA SEIYAKU KK (JP) | 1999-02-17 | — | — | EP | disclosed |
| CN-1039324-C | Substituted azacyclo-pyrimidine compounds, their pharmaceutical salts or N-oxides, and their use as anti-inflammatory agents | AMERICAN HOME PROD (US) | 1998-07-29 | — | — | CN | disclosed |
| CN-1175414-A | Method for preparing substd. azacyclopyrimidine compound, its pharmaceutic salt or N-oxide | AMERICAN HOME PROD (US) | 1998-03-11 | — | — | CN | disclosed |
| EP-0539086-B1 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PROD (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0782996-A1 | PROCESS FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVE OR SALT THEREOF AND INTERMEDIATE FOR PRODUCING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-07-09 | — | — | EP | disclosed |
| US-5498776-A | Substituted pyrrolopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-03-12 | — | — | US | disclosed |
| US-5256654-A | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| CN-1072682-A | SUBSTITUTED PYRIMIDINES | AMERICAN HOME PROD (US) | 1993-06-02 | — | — | CN | disclosed |
| EP-0539086-A2 | Condensed pyrimidine derivatives and their use as angiotensine II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-28 | — | — | EP | disclosed |
| US-5149699-A | Substituted pyridopyrimidines useful as antgiotensin II antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-22 | — | — | US | disclosed |