Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 2/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306887 | 0.73 | KCNN4 (0.44) | KCNN4HSD11B1PBRM1SLC6A2SLC6A4 | |
| SCHEMBL9283842 | 0.68 | PTGS2 (0.67) | KCNN4KMT2A | |
| SCHEMBL2447241 | 0.68 | KCNN4 (0.43) | KCNN4HSD11B1PBRM1SLC6A2SLC6A4 | |
| SCHEMBL5813523 | 0.68 | P2RX7 (0.65) | SLC6A2SLC6A4ALDH1A1LMNAKMT2A | |
| SCHEMBL9139454 | 0.68 | KCNN4 (0.52) | KCNN4HSD11B1ALDH1A1TSHRPOLB | |
| SCHEMBL9571283 | 0.68 | MAOB (0.52) | HTT | |
| SCHEMBL18920526 | 0.65 | PBRM1 (0.59) | HSD11B1PBRM1ALDH1A1TSHRLMNA | |
| SCHEMBL9139677 | 0.64 | KCNN4 (0.48) | KCNN4ALDH1A1TSHRPOLBCRHBP | |
| SCHEMBL22357731 | 0.63 | ALDH1A1 (0.50) | HSD11B1PBRM1ALDH1A1TSHRLMNA | |
| SCHEMBL12759709 | 0.63 | HSD11B1 (0.51) | HSD11B1ALDH1A1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0497150-B1 | Angiotensin II receptor blocking 2,3,6-substituted quinazolones | AMERICAN CYANAMID CO (US) | 1998-03-18 | — | — | EP | disclosed |
| US-5405849-A | Treating hypertension, congestive heart failure | AMERICAN CYANAMID COMPANY (US) | 1995-04-11 | — | — | US | disclosed |
| US-5290780-A | Hypotensive agents; congestive heart failure | AMERICAN CYANAMID CO. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0497150-A1 | Angiotensin II receptor blocking 2,3,6-substituted quinazolones | AMERICAN CYANAMID COMPANY (US) | 1992-08-05 | — | — | EP | disclosed |