SCHEMBL8307844

SCHEMBL8307844

C[Si](C)(C)c1ccc(C(Br)Br)cc1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.37
NR1H3 Q13133 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8308999 0.82 NR1H2 (0.35) NR1H2NR1H3
SCHEMBL586534 0.76 NR1H2 (0.50) NR1H2NR1H3
SCHEMBL1764658 0.76 ESR1 (0.32)
SCHEMBL6124152 0.76 TYR (0.42) NR1H2NR1H3
SCHEMBL13397172 0.75 NR1H2 (0.31) NR1H2NR1H3
SCHEMBL8737598 0.72 NR1H2 (0.35) NR1H2NR1H3
SCHEMBL8305051 0.72 ADRB2 (0.52) NR1H2NR1H3
SCHEMBL570229 0.69 CYP2A6 (0.50) NR1H2NR1H3
SCHEMBL518418 0.69 ACHE (0.50)
SCHEMBL11216352 0.69 TYR (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0555388-B1 INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES DU PONT (US) 1999-01-27 EP disclosed
US-5378708-A Agricultural pesticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-01-03 US disclosed
WO-1992008704-A1 INSECTICIDAL, ACARICIDAL AND FUNGICIDAL AMINOPYRIMIDINES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-05-29 WO disclosed