Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307013 | 0.78 | ALDH1A1 (0.45) | CA12CA1CA9KDM4EKMT2A | |
| SCHEMBL9070589 | 0.74 | CA12 (0.43) | CA12CA1CA9KDM4EKMT2A | |
| SCHEMBL9000057 | 0.74 | LMNA (0.46) | CA12CA9MAPK1SMN1; SMN2MAPT | |
| SCHEMBL8305401 | 0.72 | CA12 (0.53) | CA12CA1CA9KDM4EKMT2A | |
| SCHEMBL8307015 | 0.72 | KDM4E (0.46) | KDM4EKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL4743252 | 0.69 | ALDH1A1 (0.70) | CA12CA1CA9KMT2AMEN1 | |
| SCHEMBL9070592 | 0.68 | KDM4E (0.45) | KDM4EKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL3559572 | 0.68 | HSD17B1 (0.43) | KDM4EKMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL8554638 | 0.67 | ALDH1A1 (0.40) | KDM4EKMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL19860339 | 0.67 | TSHR (0.57) | KDM4EKMT2AMEN1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0685475-B1 | Amino-benzofuryl-and thienyl-derivatives | BAYER AG (DE) | 1999-01-13 | — | — | EP | disclosed |
| EP-0685474-B1 | Oxalylamino-benzofuran- and benzothienyl-derivatives | BAYER AG (DE) | 1998-09-16 | — | — | EP | disclosed |
| US-5622989-A | ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| US-5565488-A | ANTIINFLAMMATORY AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-10-15 | — | — | US | disclosed |
| EP-0685475-A1 | Amino-benzofuryl-and thienyl-derivatives | BAYER AG (DE) | 1995-12-06 | — | — | EP | disclosed |
| EP-0685474-A1 | Oxalylamino-benzofuran- and benzothienyl-derivatives | BAYER AG (DE) | 1995-12-06 | — | — | EP | disclosed |