Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | BRS3 | P32247 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309378 | 0.89 | PSMB1 (0.50) | PSMB1PSMB5PSMB2ALDH1A1MEN1 | |
| SCHEMBL8309254 | 0.86 | PSMB1 (0.49) | PSMB1PSMB5PSMB2ALDH1A1MEN1 | |
| SCHEMBL7354817 | 0.83 | PSMB1 (0.52) | PSMB1PSMB5PSMB2ALDH1A1MEN1 | |
| SCHEMBL7355264 | 0.83 | MMP1 (0.47) | MEN1KMT2ABRS3 | |
| SCHEMBL7358942 | 0.82 | KMT2A (0.53) | PSMB1PSMB5PSMB2MEN1KMT2A | |
| SCHEMBL7354151 | 0.81 | CTSL (0.46) | CTSL | |
| SCHEMBL7361514 | 0.81 | BACE1 (0.48) | PSMB5ALDH1A1MEN1KMT2ACTSL | |
| SCHEMBL7362211 | 0.81 | MCHR1 (0.47) | MEN1KMT2A | |
| SCHEMBL7356263 | 0.81 | TSHR (0.56) | ALDH1A1KMT2ATSHRCTSLHTT | |
| SCHEMBL7361179 | 0.80 | MME (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |