Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 10/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 6/20 | 0.49 |
| ▸ | ACE | P12821 | 5/20 | 0.49 |
| ▸ | CPA1 | P15085 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GNPAT | O15228 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355198 | 0.86 | MEN1 (0.55) | LMNA | |
| SCHEMBL7360937 | 0.85 | MMP9 (0.60) | — | |
| SCHEMBL7358942 | 0.84 | KMT2A (0.53) | — | |
| SCHEMBL8309285 | 0.83 | MMP9 (0.60) | — | |
| SCHEMBL8305171 | 0.83 | MMP9 (0.60) | — | |
| SCHEMBL7361514 | 0.83 | BACE1 (0.48) | — | |
| SCHEMBL7354151 | 0.83 | CTSL (0.46) | — | |
| SCHEMBL7355409 | 0.82 | CTSL (0.43) | — | |
| SCHEMBL7353908 | 0.81 | LAP3 (0.50) | — | |
| SCHEMBL7358288 | 0.81 | ALDH1A1 (0.63) | TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0753003-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995028416-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-26 | — | — | WO | disclosed |