Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RPA1 | P27694 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309863 | 0.83 | GAA (0.60) | HTTKDM4EALDH1A1GAAMAPT | |
| SCHEMBL8915716 | 0.77 | ADORA1 (0.59) | KDM4EALDH1A1GAAMAPTADORA1 | |
| SCHEMBL14833516 | 0.76 | BRAF (0.58) | KDM4EALDH1A1GAAMAPTADORA1 | |
| SCHEMBL8917674 | 0.75 | ALDH1A1 (0.58) | HTTKDM4EALDH1A1GAAMAPT | |
| SCHEMBL8309622 | 0.75 | MAPT (0.57) | KDM4EALDH1A1GAACYP1A2CYP2C9 | |
| SCHEMBL18988429 | 0.75 | ADORA1 (0.56) | KDM4EALDH1A1GAAMAPTADORA1 | |
| SCHEMBL8914681 | 0.72 | PLAUR (0.51) | HTTKDM4EALDH1A1GAAMAPT | |
| SCHEMBL8915404 | 0.72 | ALDH1A1 (0.49) | HTTKDM4EALDH1A1GAAMAPT | |
| SCHEMBL8308061 | 0.72 | GAA (0.53) | KDM4EALDH1A1GAAMAPTTSHR | |
| SCHEMBL27847239 | 0.71 | ADORA1 (0.54) | HTTKDM4EALDH1A1MAPTADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593997-A | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |