Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 8/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.48 |
| ▸ | CHRNG | P07510 | 4/20 | 0.48 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.48 |
| ▸ | CHRND | Q07001 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310244 | 0.90 | PLG (0.49) | PLGPRSS1PRSS2PRSS3CHRNA1 | |
| SCHEMBL8875868 | 0.90 | PLG (0.53) | PLGPRSS1PRSS2PRSS3L3MBTL1 | |
| SCHEMBL7362758 | 0.87 | GAA (0.48) | PLGPRSS1PRSS2PRSS3CHRNA1 | |
| SCHEMBL7356539 | 0.87 | L3MBTL1 (0.47) | PLGPRSS1PRSS2PRSS3CHRNA1 | |
| SCHEMBL7356782 | 0.83 | GRIA1 (0.48) | CHRNA1CHRNGCHRNB1CHRNDL3MBTL1 | |
| SCHEMBL8306010 | 0.82 | MMP8 (0.50) | L3MBTL1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7358942 | 0.82 | KMT2A (0.53) | L3MBTL1 | |
| SCHEMBL7363911 | 0.81 | CHRNA1 (0.58) | CHRNA1CHRNGCHRNB1CHRNDCHRNB2 | |
| SCHEMBL7353908 | 0.81 | LAP3 (0.50) | L3MBTL1 | |
| SCHEMBL7363069 | 0.80 | PLG (0.52) | PLGPRSS1PRSS2PRSS3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |