Sugi Predict

Sugi Predict / Compounds / SCHEMBL8310508

SCHEMBL8310508

SCHEMBL8310508

CCCCCc1coc2c1C(=O)C=C2

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ACHE P22303 1/20 0.41
▸ BACE1 P56817 1/20 0.41
▸ HCAR2 Q8TDS4 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ CTRC Q99895 1/20 0.33
▸ NR1H2 P55055 1/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ MAPT P10636 2/20 0.31
▸ ELANE P08246 1/20 0.31
▸ CTSG P08311 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ PDF Q9HBH1 1/20 0.31
▸ ALOX5 P09917 9/20 0.31
▸ MPEG1 Q2M385 7/20 0.31
▸ XIAP P98170 2/20 0.31
▸ GPR84 Q9NQS5 2/20 0.31
▸ FAAH O00519 1/20 0.31
▸ MGLL Q99685 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30003055 0.67 POLM (0.51) ACHEBACE1TDP1NR1H2NR1H3
SCHEMBL23271654 0.67 POLM (0.51) ACHEBACE1TDP1NR1H2NR1H3
SCHEMBL8336398 0.66 PDF (0.41) TDP1MAPTPDFMEN1USP2
SCHEMBL28655350 0.65 ACHE (0.55) ACHEBACE1TDP1MAPTALOX5
SCHEMBL28345511 0.65 ELANE (0.43) ACHEBACE1TDP1NR1H2NR1H3
SCHEMBL28357045 0.65 ELANE (0.43) ACHEBACE1TDP1NR1H2NR1H3
SCHEMBL16701741 0.63 TYR (0.42) ACHETDP1MAPTSMN1; SMN2ALOX5
SCHEMBL8395883 0.63 GAA (0.49) NR1H2NR1H3MAPTSMN1; SMN2KDM4E
SCHEMBL8792802 0.63 LIPG (0.42) ACHETDP1MAPTALOX5KDM4E
SCHEMBL27816116 0.62 BID (0.51) MAPTKDM4EPTGESALOX15KAT2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1553949-B1 PYRIMIDINE-2,4-DIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER LAMBERT CO (US) 2007-04-18 — — EP disclosed
US-7160893-B2 Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors WARNER-LAMBERT COMPANY (US) 2007-01-09 — — US disclosed
US-7160893-B2 Pyrimidine-2,4-dione derivatives as matrix metalloproteinase inhibitors WARNER-LAMBERT COMPANY (US) 2007-01-09 — — US disclosed
WO-2004064842-A1 AMIDE AND ESTER MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-08-05 — — WO disclosed
WO-2004014384-A2 CYCLIC COMPOUNDS CONTAINING ZINC BINDING GROUPS AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014354-A1 1,6-FUSED URACIL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014921-A1 5,6-FUSED URACIL DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014389-A1 3,4-DIHYDROQUINOLIN-2-ONE, 5,6-FUSED OXAZIN-3-ONE, AND 5,6-FUSED THIAZIN-3-ONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014365-A1 PHTHALIMIDE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014880-A1 CHROMONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014909-A1 FUSED TETRAHYDROPYRIDINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed
WO-2004014866-A1 AZAISOQUINOLINE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS WARNER-LAMBERT COMPANY LLC (US) 2004-02-19 — — WO disclosed