Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.35 |
| ▸ | RARB | P10826 | 3/20 | 0.35 |
| ▸ | RARG | P13631 | 3/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 8/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 8/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8314991 | 0.99 | RARA (0.35) | RARARARBRARGDGAT1CDC7 | |
| SCHEMBL8310822 | 0.89 | TRPM8 (0.35) | RARARARBRARGDGAT1CDC7 | |
| SCHEMBL8316119 | 0.81 | ALOX5 (0.40) | RARARARBRARGCDC7DBF4 | |
| Hydrochloric Acid SCHEMBL8311441 | 0.80 | NQO2 (0.35) | — | |
| Hydrochloric Acid SCHEMBL8313224 | 0.80 | F10 (0.36) | — | |
| Hydrochloric Acid SCHEMBL8311435 | 0.80 | PDE4B (0.30) | — | |
| SCHEMBL8315862 | 0.79 | ALOX5 (0.44) | NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8315777 | 0.78 | KDM4E (0.50) | NPC1PKMNFKB1RAB9ANFKB2 | |
| Hydrochloric Acid SCHEMBL8315893 | 0.76 | MAPT (0.38) | TRPM8NPC1RAB9ASMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL8312117 | 0.75 | RAB9A (0.42) | NPC1PKMRAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |