Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308971 | 0.88 | MAPT (0.43) | LMNATP53RXFP1MAPTTHRB | |
| SCHEMBL8305086 | 0.81 | BRPF1 (0.46) | TP53MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL8308192 | 0.80 | KMT2A (0.58) | LMNAMAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL8307433 | 0.76 | CYP19A1 (0.65) | LMNATP53MAPTTHRBKDM4E | |
| SCHEMBL11688437 | 0.76 | KMT2A (0.66) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12278263 | 0.76 | KDM4E (0.41) | LMNATP53MAPTTHRBKDM4E | |
| SCHEMBL8304877 | 0.74 | MAPK1 (0.42) | LMNATP53MAPTTHRBKDM4E | |
| SCHEMBL12278045 | 0.74 | KDM4E (0.40) | TP53MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL12278761 | 0.74 | MAOA (0.41) | TP53MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL9198888 | 0.69 | KDM4E (0.46) | LMNAMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650599-B1 | METHOD OF COLORIMETRIC ANALYSIS OF MALONIC DIALDEHYDE AND 4-HYDROXY-2-ENALDEHYDES AS INDEXES OF LIPID PEROXIDATION, KITS FOR CARRYING OUT SAID METHOD, SUBSTITUTED INDOLES FOR USE IN SAID METHOD AND THEIR PREPARATION | OXIS ISLE OF MAN LIMITED (GB) | 1999-11-03 | — | — | EP | disclosed |
| US-5726063-A | Method of colorimetric analysis of malonic dialdehyde and 4-hydroxy-2-enaldehydes as indexes of lipid peroxidation, kits for carrying out said method, substituted indoles for use in said method and their preparation | OXIS ISLE OF MAN, LIMITED (US) | 1998-03-10 | — | — | US | disclosed |