Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312914 | 0.89 | TP53 (0.53) | TP53CYP1A2MAPTCYP1A1CYP2D6 | |
| SCHEMBL8317248 | 0.89 | PTGS2 (0.52) | PTGS2TP53CYP1A2MAPTALDH1A1 | |
| SCHEMBL8317573 | 0.87 | KMT2A (0.52) | TP53MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL8313606 | 0.84 | TP53 (0.56) | TP53MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL8311389 | 0.82 | SMN1; SMN2 (0.54) | PTGS2CYP1A2MAPTCYP1A1CYP2D6 | |
| SCHEMBL8311715 | 0.82 | L3MBTL1 (0.53) | PTGS2MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL8311933 | 0.82 | ALDH1A1 (0.49) | PTGS2TP53CYP1A2MAPTALDH1A1 | |
| SCHEMBL8314109 | 0.82 | HDAC8 (0.50) | PTGS2CYP1A2MAPTCYP2D6ALDH1A1 | |
| SCHEMBL8312845 | 0.81 | RECQL (0.54) | PTGS2TP53CYP1A2MAPTCYP2D6 | |
| SCHEMBL8313443 | 0.81 | ALDH1A1 (0.54) | CYP1A2MAPTALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |