Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313606 | 0.91 | TP53 (0.56) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL8311933 | 0.89 | ALDH1A1 (0.49) | RECQLALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL8317573 | 0.84 | KMT2A (0.52) | ALDH1A1MEN1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL8317248 | 0.83 | PTGS2 (0.52) | ALDH1A1SMN1; SMN2MAPTNPSR1RAB9A | |
| SCHEMBL8313214 | 0.83 | TP53 (0.47) | ALDH1A1MAPTRAB9ALMNATP53 | |
| SCHEMBL8315347 | 0.82 | TP53 (0.46) | ALDH1A1MAPTRAB9ALMNATP53 | |
| SCHEMBL8312914 | 0.82 | TP53 (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL8314971 | 0.81 | MAOB (0.48) | ALDH1A1SMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL8312438 | 0.81 | PTGS2 (0.45) | ALDH1A1MEN1KMT2AMAPTRAB9A | |
| SCHEMBL8311715 | 0.81 | L3MBTL1 (0.53) | RECQLALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |