Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.47 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.47 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.47 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.47 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.47 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.47 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.47 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.47 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.47 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.47 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.47 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.47 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.47 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.47 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313606 | 0.88 | TP53 (0.56) | KMT2AMAPK1KDM4EALDH1A1HPGD | |
| SCHEMBL8312438 | 0.87 | PTGS2 (0.45) | KMT2AALDH1A1LMNATP53MAPT | |
| SCHEMBL8311933 | 0.85 | ALDH1A1 (0.49) | ALDH1A1LMNATP53MAPTRAB9A | |
| SCHEMBL8312845 | 0.84 | RECQL (0.54) | KMT2AMAPK1ALDH1A1HPGDLMNA | |
| SCHEMBL8311846 | 0.83 | ABCG2 (0.48) | KMT2AMAPK1OPRK1ALDH1A1LMNA | |
| SCHEMBL8317248 | 0.83 | PTGS2 (0.52) | ALDH1A1HTTSMN1; SMN2GAATP53 | |
| SCHEMBL8311233 | 0.82 | NFE2L2 (0.50) | KMT2AKDM4EALDH1A1HPGDHTT | |
| SCHEMBL9205578 | 0.82 | MAPK1 (0.68) | KMT2AMAPK1OPRK1MEN1POLB | |
| SCHEMBL8312914 | 0.81 | TP53 (0.53) | KMT2AALDH1A1HPGDLMNASMN1; SMN2 | |
| SCHEMBL8311160 | 0.81 | RAB9A (0.53) | KMT2AKDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |