SCHEMBL8312678

SCHEMBL8312678

CCOC(=O)C(=O)NC1Cc2ccc(Cl)cc2C1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
GAA P10253 3/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
TDP1 Q9NUW8 1/20 0.46
KDM4E B2RXH2 3/20 0.41
MAPT P10636 2/20 0.41
MEN1 O00255 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.41
HSD17B10 Q99714 1/20 0.41
PTPN1 P18031 1/20 0.41
GPR35 Q9HC97 2/20 0.39
CYP19A1 P11511 1/20 0.38
MME P08473 1/20 0.38
ACE P12821 1/20 0.38
SPR P35270 1/20 0.37
GPBAR1 Q8TDU6 1/20 0.37
HTT P42858 1/20 0.36
MAPK1 P28482 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8312673 0.84 CYP11B1 (0.36) SMN1; SMN2KDM4ENPSR1
SCHEMBL8319741 0.83 MAPT (0.45) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL31650408 0.72 ALDH1A1 (0.45) ALDH1A1GAASMN1; SMN2TDP1KDM4E
SCHEMBL605776 0.72 ACHE (0.52) ALDH1A1GAAKDM4EMAPTMEN1
SCHEMBL8478504 0.71 GAA (0.44) ALDH1A1GAASMN1; SMN2TDP1KDM4E
SCHEMBL23460007 0.69 MEN1 (0.57) ALDH1A1GAAKDM4EMAPTMEN1
SCHEMBL8882302 0.68 GABRG2 (0.40) ALDH1A1GAASMN1; SMN2KDM4EMAPT
SCHEMBL11529301 0.68 METAP1 (0.52) ALDH1A1GAAKDM4EMAPTMEN1
SCHEMBL8307518 0.68 KDM4E (0.43) GAASMN1; SMN2KDM4EMAPTHPGD
SCHEMBL8573564 0.68 PYGL (0.36) SMN1; SMN2KDM4EKMT2ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922716-A 5H-indeno 1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them RHONE-POULENC RORER S.A. (FR) 1999-07-13 US disclosed
EP-0752988-B1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS RHONE POULENC RORER SA (FR) 1999-05-26 EP disclosed
EP-0752988-A1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-01-15 EP disclosed
WO-1995026342-A1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1995-10-05 WO disclosed