SCHEMBL8319741

SCHEMBL8319741

CCOC(=O)C(=O)NC1Cc2ccccc2C1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.45
MAPK1 P28482 1/20 0.44
ATM Q13315 1/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
ACHE P22303 1/20 0.42
ALDH1A1 P00352 4/20 0.41
GAA P10253 3/20 0.41
METAP1 P53582 2/20 0.40
HPGD P15428 2/20 0.39
LMNA P02545 1/20 0.39
MPI P34949 1/20 0.39
HTT P42858 1/20 0.39
IDO1 P14902 1/20 0.39
TDO2 P48775 1/20 0.39
KMT2A Q03164 2/20 0.39
HRH4 Q9H3N8 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8312678 0.83 ALDH1A1 (0.46) MAPTMAPK1SMN1; SMN2ALDH1A1GAA
SCHEMBL8319737 0.82 ACHE (0.45) MAPTMAPK1ATMSMN1; SMN2NPC1
SCHEMBL10947753 0.77 ACHE (0.49) MAPTMAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL10947764 0.77 ACHE (0.49) MAPTMAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL2919195 0.77 MAPT (0.51) MAPTMAPK1ATMSMN1; SMN2ACHE
Ethylene SCHEMBL9316053 0.75 ACHE (0.46) MAPTMAPK1SMN1; SMN2NPC1RAB9A
SCHEMBL20622380 0.75 L3MBTL1 (0.42) MAPTSMN1; SMN2NPC1RAB9AALDH1A1
SCHEMBL8797208 0.75 ACHE (0.49) MAPTMAPK1ATMSMN1; SMN2NPC1
SCHEMBL31460799 0.73 MAPT (0.70) MAPTMAPK1ATMSMN1; SMN2RAB9A
SCHEMBL490810 0.73 MAPT (0.70) MAPTMAPK1ATMSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5922716-A 5H-indeno 1,2-b!pyrazine-2,3-dione derivatives, their preparation and medicinal products containing them RHONE-POULENC RORER S.A. (FR) 1999-07-13 US disclosed
EP-0752988-B1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES ANTAGONISTS OF AMPA AND NMDA RECEPTORS RHONE POULENC RORER SA (FR) 1999-05-26 EP disclosed
EP-0752988-A1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-01-15 EP disclosed
WO-1995026342-A1 5H-INDENO[1,2-b]PYRAZINE-2,3-DIONE DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1995-10-05 WO disclosed