Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318785 | 0.90 | KMT2A (0.43) | OPRK1DPP4KMT2AGAAMEN1 | |
| SCHEMBL8317336 | 0.89 | OPRK1 (0.35) | OPRK1DPP4OPRM1KMT2AGAA | |
| SCHEMBL8317047 | 0.89 | OPRK1 (0.35) | OPRK1DPP4OPRM1KMT2AGAA | |
| SCHEMBL8317634 | 0.86 | KMT2A (0.40) | OPRK1DPP4KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8316253 | 0.85 | CYP3A4 (0.33) | OPRK1KMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL8317349 | 0.83 | GAA (0.35) | OPRK1DPP4OPRM1KMT2AGAA | |
| SCHEMBL8318503 | 0.83 | ALDH1A1 (0.34) | KMT2AGAAMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8878241 | 0.83 | KMT2A (0.38) | DPP4KMT2AGAAMEN1SMN1; SMN2 | |
| SCHEMBL8310881 | 0.83 | ALDH1A1 (0.39) | OPRK1OPRM1KMT2AGAAMEN1 | |
| SCHEMBL9539327 | 0.81 | OPRK1 (0.42) | OPRK1OPRM1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |