Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317336 | 0.89 | OPRK1 (0.35) | OPRK1DPP4OPRM1KMT2AGAA | |
| SCHEMBL8315579 | 0.89 | KMT2A (0.43) | OPRK1KMT2AGAAVHLMEN1 | |
| SCHEMBL8312982 | 0.89 | OPRK1 (0.35) | OPRK1DPP4OPRM1SLC6A4SLC6A3 | |
| SCHEMBL8312980 | 0.86 | KMT2A (0.40) | OPRK1DPP4KMT2AGAAMEN1 | |
| SCHEMBL8317543 | 0.84 | VHL (0.34) | OPRK1KMT2AVHLMEN1ALDH1A1 | |
| SCHEMBL8317349 | 0.83 | GAA (0.35) | OPRK1DPP4OPRM1SLC6A4SLC6A3 | |
| SCHEMBL8310881 | 0.83 | ALDH1A1 (0.39) | OPRK1OPRM1KMT2AGAAMEN1 | |
| SCHEMBL8317651 | 0.82 | PIK3CD (0.39) | KMT2AGAAVHLMEN1SMN1; SMN2 | |
| SCHEMBL8983664 | 0.82 | VHL (0.40) | DPP4SLC6A4SLC6A3KMT2AGAA | |
| SCHEMBL9539327 | 0.81 | OPRK1 (0.42) | OPRK1OPRM1SLC6A3KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |