Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318503 | 0.89 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ANLRP3 | |
| SCHEMBL8317543 | 0.87 | VHL (0.34) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8313957 | 0.87 | ALDH1A1 (0.33) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8314255 | 0.86 | CYP3A4 (0.35) | CYP3A4MEN1KMT2ANLRP3POLB | |
| SCHEMBL8312982 | 0.85 | OPRK1 (0.35) | CYP3A4ALDH1A1MEN1KMT2APOLB | |
| SCHEMBL8318785 | 0.82 | KMT2A (0.43) | CYP3A4ALDH1A1MEN1KMT2ANLRP3 | |
| SCHEMBL8316437 | 0.82 | MEN1 (0.33) | CYP3A4ALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL8878158 | 0.81 | POLB (0.36) | ALDH1A1MEN1KMT2AMAPK1POLB | |
| SCHEMBL8314818 | 0.81 | KMT2A (0.37) | MEN1KMT2AMAPK1NLRP3POLB | |
| SCHEMBL9536573 | 0.79 | MEN1 (0.43) | MEN1KMT2AMAPK1POLBOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |