Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312741 | 0.91 | CBFB (0.39) | CBFBSMN1; SMN2NPC1MAPK1RAB9A | |
| SCHEMBL8315309 | 0.82 | ADRA1A (0.38) | SMN1; SMN2NPC1RAB9ALMNAMAPT | |
| SCHEMBL8311146 | 0.82 | ABCC9 (0.34) | CBFBTGFBR1PDK2KCNH2 | |
| SCHEMBL8316184 | 0.81 | KDM4E (0.37) | SMN1; SMN2NPC1MAPK1RAB9AGAA | |
| SCHEMBL8311427 | 0.81 | SCN9A (0.35) | CBFBMAPK1RAB9AALDH1A1LMNA | |
| SCHEMBL8313018 | 0.79 | METAP2 (0.39) | TGFBR1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8316296 | 0.78 | CCR1 (0.35) | SMN1; SMN2NPC1MAPK1RAB9AALDH1A1 | |
| SCHEMBL8314584 | 0.77 | FABP6 (0.37) | CBFBRAB9ATGFBR1MAPTGRM5 | |
| SCHEMBL8315666 | 0.77 | NTRK1 (0.35) | NPC1RAB9AALDH1A1MAPTGRM5 | |
| SCHEMBL8315603 | 0.76 | CBFB (0.42) | CBFBGRM5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5602152-A | POTASSIUM CHANNEL MODULATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |
| WO-1994013658-A2 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1994-06-23 | — | — | WO | disclosed |