Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 12/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313790 | 0.91 | TGFBR1 (0.39) | METAP2METAP1GRM5TGFBR1MAPK13 | |
| SCHEMBL8315309 | 0.82 | ADRA1A (0.38) | METAP1GRM5KDM4EHTTMAPT | |
| SCHEMBL8315902 | 0.82 | MAOA (0.33) | GRM5TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL8311893 | 0.82 | MAOA (0.35) | GRM5TGFBR1MAPK13MAPK12MAPK11 | |
| SCHEMBL8316184 | 0.81 | KDM4E (0.37) | METAP1KCNH2KDM4EHTTALDH1A1 | |
| SCHEMBL8313240 | 0.79 | CBFB (0.39) | GRM5TGFBR1KCNH2KDM4EALDH1A1 | |
| SCHEMBL8316296 | 0.78 | CCR1 (0.35) | METAP1GRM5KDM4EHTTALDH1A1 | |
| SCHEMBL8311427 | 0.78 | SCN9A (0.35) | METAP1GRM5KCNH2KDM4EALDH1A1 | |
| SCHEMBL8875966 | 0.76 | NPY5R (0.34) | METAP1KDM4EHTTKMT2A | |
| SCHEMBL8332841 | 0.76 | METAP2 (0.40) | METAP2METAP1GRM5TGFBR1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626954-B1 | BENZOCYCLOHEPTENES, BENZOXEPINES AND BENZOTHIEPINES | MERCK PATENT GMBH (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5602152-A | POTASSIUM CHANNEL MODULATOR | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-02-11 | — | — | US | disclosed |