Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317318 | 0.88 | POLB (0.35) | CYP3A4SMN1; SMN2P2RX7L3MBTL1KMT2A | |
| SCHEMBL8317180 | 0.88 | CYP3A4 (0.35) | CYP3A4SMN1; SMN2P2RX7L3MBTL1KMT2A | |
| SCHEMBL8316253 | 0.86 | CYP3A4 (0.33) | CYP3A4KMT2AMEN1POLBNLRP3 | |
| SCHEMBL8317634 | 0.84 | KMT2A (0.40) | CYP3A4SMN1; SMN2P2RX7KMT2AMEN1 | |
| SCHEMBL8317561 | 0.83 | CYP3A4 (0.35) | CYP3A4SMN1; SMN2P2RX7L3MBTL1KMT2A | |
| SCHEMBL8877111 | 0.83 | ALDH1A1 (0.37) | SMN1; SMN2P2RX7KMT2AHCRTR1HCRTR2 | |
| SCHEMBL8317692 | 0.82 | POLB (0.35) | SMN1; SMN2P2RX7L3MBTL1KMT2AMEN1 | |
| SCHEMBL8318503 | 0.81 | ALDH1A1 (0.34) | SMN1; SMN2KMT2AHCRTR1HCRTR2MEN1 | |
| SCHEMBL9536076 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2L3MBTL1KMT2AMEN1POLB | |
| SCHEMBL9386544 | 0.80 | SMN1; SMN2 (0.34) | CYP3A4SMN1; SMN2P2RX7L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |