Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317180 | 0.89 | CYP3A4 (0.35) | POLBCYP3A4SMN1; SMN2KMT2AP2RX7 | |
| SCHEMBL8314255 | 0.88 | CYP3A4 (0.35) | POLBCYP3A4SMN1; SMN2KMT2AP2RX7 | |
| SCHEMBL8317543 | 0.85 | VHL (0.34) | POLBCYP3A4CYP1A2CYP2C19APOBEC3A | |
| SCHEMBL8317561 | 0.84 | CYP3A4 (0.35) | POLBCYP3A4SMN1; SMN2KMT2AP2RX7 | |
| SCHEMBL8312980 | 0.83 | KMT2A (0.40) | CYP3A4SMN1; SMN2KMT2AP2RX7MEN1 | |
| SCHEMBL8317692 | 0.83 | POLB (0.35) | POLBSMN1; SMN2KMT2AP2RX7L3MBTL1 | |
| SCHEMBL8879447 | 0.82 | POLB (0.41) | POLBCYP3A4CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL9536076 | 0.81 | SMN1; SMN2 (0.38) | POLBSMN1; SMN2KMT2AL3MBTL1MEN1 | |
| SCHEMBL8317651 | 0.81 | PIK3CD (0.39) | POLBSMN1; SMN2KMT2AVHLPIK3CD | |
| SCHEMBL9386544 | 0.80 | SMN1; SMN2 (0.34) | POLBCYP3A4SMN1; SMN2KMT2AP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |