Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.81 |
| ▸ | DRD4 | P21917 | 9/20 | 0.81 |
| ▸ | DRD3 | P35462 | 9/20 | 0.81 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.46 |
| ▸ | RELA | Q04206 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314007 | 0.90 | DRD2 (0.81) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8312627 | 0.90 | DRD2 (0.81) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8312005 | 0.90 | DRD2 (1.00) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8313970 | 0.87 | DRD2 (0.77) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8314765 | 0.79 | DRD2 (0.68) | DRD2DRD4DRD3NFKB1NFKB2 | |
| SCHEMBL8317510 | 0.77 | DRD2 (0.64) | DRD2DRD4DRD3 | |
| SCHEMBL8643128 | 0.77 | DRD2 (0.64) | DRD2DRD4DRD3 | |
| SCHEMBL5957081 | 0.71 | DRD2 (0.55) | DRD2DRD4DRD3KMT2A | |
| SCHEMBL5957139 | 0.71 | DRD2 (0.55) | DRD2DRD4DRD3KMT2A | |
| Aplindore SCHEMBL119499 | 0.71 | DRD2 (0.68) | DRD2DRD4DRD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | claimed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | claimed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | claimed |
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |
| EP-0750611-A1 | ANILIDE DERIVATIVES AS FUNGICIDES | AgrEvo UK Limited (GB) | 1997-01-02 | — | — | EP | disclosed |