Sugi Predict

Sugi Predict / Compounds / SCHEMBL8314477

SCHEMBL8314477

SCHEMBL8314477

CNC(=O)Cc1ccccc1OC

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.63
▸ KMT2A Q03164 3/20 0.63
▸ TSHR P16473 2/20 0.63
▸ MAPT P10636 1/20 0.63
▸ TAAR1 Q96RJ0 1/20 0.61
▸ NPC1 O15118 1/20 0.60
▸ RAB9A P51151 1/20 0.60
▸ GAA P10253 2/20 0.60
▸ ATM Q13315 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ NPSR1 Q6W5P4 2/20 0.56
▸ HPGD P15428 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ POLB P06746 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6207654 0.98 MEN1 (0.61) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL8566606 0.85 MEN1 (0.49) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL13619977 0.84 ATM (0.59) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL26333757 0.84 ATM (0.62) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL29907950 0.84 GAA (0.64) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL2826584 0.84 GAA (0.64) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL18089027 0.83 MTNR1A (0.58) KMT2ATSHRNPC1RAB9ASMN1; SMN2
SCHEMBL19751948 0.83 ATM (0.65) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL30027909 0.81 MEN1 (0.58) MEN1KMT2ATSHRMAPTTAAR1
SCHEMBL468013 0.81 MEN1 (0.58) MEN1KMT2ATSHRMAPTTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116528857-A MALT-1 modulators 艾克斯赛安西娅人工智能有限公司 2023-08-01 — — CN disclosed
WO-2021104486-A1 COMPOUND CONTAINING BENZENE RING AND APPLICATION THEREOF 武汉朗来科技发展有限公司 2021-06-03 — — WO disclosed
US-20180310562-A1 FUNGICIDAL PYRAZOLE MIXTURES FMC CORP (US) 2018-11-01 — — US disclosed
US-10015966-B2 Fungicidal pyrazole mixtures E I DU PONT DE NEMOURS AND COMPANY (US) 2018-07-10 — — US disclosed
US-20170260142-A1 SOLID FORMS OF FUNGICIDAL PYRAZOLES DU PONT (US) 2017-09-14 — — US disclosed
US-9688639-B2 Solid forms of fungicidal pyrazoles E I DU PONT DE NEMOURS AND COMPANY (US) 2017-06-27 — — US disclosed
US-20160242416-A1 FUNGICIDAL ISOXAZOLINE CARBINOLS DU PONT (US) 2016-08-25 — — US disclosed
US-20160075661-A1 SOLID FORMS OF FUNGICIDAL PYRAZOLES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2016-03-17 — — US disclosed
WO-2015157005-A1 SUBSTITUTED TOLYL FUNGICIDE MIXTURES E I DU PONT DE NEMOURS AND COMPANY (US) 2015-10-15 — — WO disclosed
US-20150266850-A1 SUBSTITUTED TOLYL FUNGICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2015-09-24 — — US disclosed
US-20120165309-A1 HETERO RING DERIVATIVE ASTELLAS PHARMA INC. (JP) 2012-06-28 — — US disclosed
EP-2397479-A1 HETERO RING DERIVATIVE Astellas Pharma Inc. (JP) 2011-12-21 — — EP disclosed
WO-2010092962-A1 HETERO RING DERIVATIVE アステラス製薬株式会社 (JP) 2010-08-19 — — WO disclosed
US-20100113371-A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds RANBAXY LABORATORIES LIMITED INC. (IN) 2010-05-06 — — US disclosed
US-20100113371-A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds RANBAXY LABORATORIES LIMITED INC. (IN) 2010-05-06 — — US disclosed
US-20090075909-A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds RANBAXY LABORATORIES LIMITED INC. (IN) 2009-03-19 — — US disclosed
US-20090075909-A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds RANBAXY LABORATORIES LIMITED INC. (IN) 2009-03-19 — — US disclosed
EP-0636625-B1 Tricyclic diazepines vasopressin and oxytocin antagonists AMERICAN CYANAMID CO (US) 1999-01-27 — — EP disclosed
EP-0772601-A1 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-05-14 — — EP disclosed
WO-1996003387-A1 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-02-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090075909-A1 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds HLA-DRB1, IL5, TNF MEN1 3635/4885KMT2A 4338/4885TSHR 3110/4885
US-20150266850-A1 SUBSTITUTED TOLYL FUNGICIDES TH, CYP1B1, CYP1A1 MEN1 1793/4885KMT2A 3392/4885TSHR 1379/4885
US-20120165309-A1 HETERO RING DERIVATIVE IL2, PIK3R2, IL2RA MEN1 4630/4885KMT2A 1656/4885TSHR 1779/4885
US-20170260142-A1 SOLID FORMS OF FUNGICIDAL PYRAZOLES NOD1, AFF1, MAST1 MEN1 1990/4885KMT2A 3857/4885TSHR 4163/4885
US-10015966-B2 Fungicidal pyrazole mixtures CYP1B1, CBR3, CBR1 MEN1 1666/4885KMT2A 4555/4885TSHR 2226/4885
US-20160242416-A1 FUNGICIDAL ISOXAZOLINE CARBINOLS CYP1B1, CHRM1, CYP1A1 MEN1 2476/4885KMT2A 1675/4885TSHR 3040/4885
US-20160075661-A1 SOLID FORMS OF FUNGICIDAL PYRAZOLES NOD1, AFF1, MAST1 MEN1 1990/4885KMT2A 3857/4885TSHR 4163/4885
US-20180310562-A1 FUNGICIDAL PYRAZOLE MIXTURES CYP1B1, CBR3, CBR1 MEN1 1666/4885KMT2A 4555/4885TSHR 2226/4885
US-20100113371-A9 Derivatives Of Pentose Monosaccharides As Anti-Inflammatory Compounds HLA-DRB1, IL5, TNF MEN1 3635/4885KMT2A 4338/4885TSHR 3110/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.