Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 5/20 | 0.39 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.39 |
| ▸ | MCHR2 | Q969V1 | 8/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | UBA1 | P22314 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312220 | 0.80 | NAE1 (0.47) | NAE1UBA3UBA1 | |
| SCHEMBL8310625 | 0.80 | NAE1 (0.38) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL1222483 | 0.77 | HSD11B1 (0.43) | MCHR2SIGMAR1EGFROPRM1CYP3A4 | |
| SCHEMBL12084760 | 0.75 | MCHR2 (0.53) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL7632592 | 0.75 | MCHR2 (0.53) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL652661 | 0.74 | OPRM1 (0.43) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL12084784 | 0.74 | OPRM1 (0.43) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL8100165 | 0.73 | MCHR2 (0.42) | NAE1UBA3MCHR2DRD2SLC6A4 | |
| SCHEMBL14272835 | 0.73 | SIGMAR1 (0.40) | NAE1UBA3MCHR2SIGMAR1KCNH2 | |
| SCHEMBL30488771 | 0.73 | SIGMAR1 (0.40) | NAE1UBA3MCHR2SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |