Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.35 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14272835 | 1.00 | SIGMAR1 (0.40) | SIGMAR1HSD11B1BACE1OPRD1KCNH2 | |
| SCHEMBL231633 | 1.00 | SIGMAR1 (0.40) | SIGMAR1HSD11B1BACE1OPRD1KCNH2 | |
| SCHEMBL8106137 | 0.86 | OPRM1 (0.46) | SIGMAR1MAPTOPRM1POLBPKM | |
| SCHEMBL13689881 | 0.86 | KDM1A (0.37) | SIGMAR1HSD11B1OPRD1KCNH2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8316273 | 0.85 | OPRM1 (0.45) | SIGMAR1MAPTOPRM1POLBPKM | |
| SCHEMBL651529 | 0.84 | HSD11B1 (0.40) | SIGMAR1HSD11B1OPRD1KCNH2CYP3A4 | |
| SCHEMBL1222859 | 0.83 | HSD11B1 (0.51) | SIGMAR1HSD11B1OPRD1KCNH2ALDH1A1 | |
| SCHEMBL9966031 | 0.83 | HSD11B1 (0.47) | SIGMAR1HSD11B1OPRD1KCNH2CYP3A4 | |
| SCHEMBL14300920 | 0.82 | HSD11B1 (0.46) | SIGMAR1HSD11B1BACE1OPRD1KCNH2 | |
| SCHEMBL14530302 | 0.81 | OPRD1 (0.54) | SIGMAR1HSD11B1OPRD1KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12209094-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2025-01-28 | — | — | US | disclosed |
| US-11731981-B2 | CCR2 receptor antagonists and uses thereof | CENTREXION THERAPEUTICS CORPORATION (US) | 2023-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11731981-B2 | CCR2 receptor antagonists and uses thereof | CCR2, CCRL2, CCR1 | SIGMAR1 1047/4885HSD11B1 1354/4885BACE1 4156/4885 |
| US-12209094-B2 | CCR2 receptor antagonists and uses thereof | CCR2, CCRL2, CCR1 | SIGMAR1 1047/4885HSD11B1 1354/4885BACE1 4156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.