Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27349990 | 1.00 | ALDH1A1 (0.54) | ALDH1A1KMT2ALDHAF2RL1GLA | |
| SCHEMBL6401372 | 1.00 | ALDH1A1 (0.54) | ALDH1A1KMT2ALDHAF2RL1GLA | |
| SCHEMBL8239150 | 0.88 | PPARA (0.64) | ALDH1A1KMT2APPARGPPARA | |
| SCHEMBL12305803 | 0.88 | PPARA (0.64) | ALDH1A1KMT2APPARGPPARA | |
| SCHEMBL6404868 | 0.87 | ALDH1A1 (0.50) | ALDH1A1KMT2ALDHAF2RL1GLA | |
| SCHEMBL12256772 | 0.87 | TGM2 (0.48) | ALDH1A1PPARGPPARASMN1; SMN2ATM | |
| SCHEMBL627389 | 0.86 | MME (0.52) | ALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL627390 | 0.86 | MME (0.52) | ALDH1A1KMT2ASMN1; SMN2HTT | |
| SCHEMBL7406394 | 0.85 | FPR2 (0.48) | KMT2AFPR2 | |
| SCHEMBL8305419 | 0.85 | PPARA (0.46) | ALDH1A1PPARGPPARAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| CN-1040432-C | Spiro piperdines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1998-10-28 | — | — | CN | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994019367-A1 | SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |