Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | XDH | P47989 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311780 | 0.89 | CA1 (0.51) | CA1CA2XDHCA12CA7 | |
| SCHEMBL18176754 | 0.88 | TSHR (0.44) | CA1CA2XDHCA12CA7 | |
| SCHEMBL27342343 | 0.85 | TSHR (0.44) | CA1CA2XDHCA12CA7 | |
| SCHEMBL17432114 | 0.85 | P4HB (0.47) | CA1CA2XDHCA12CA7 | |
| Bromide SCHEMBL28461450 | 0.84 | TSHR (0.42) | CA1CA2XDHCA12CA7 | |
| SCHEMBL13866784 | 0.82 | VCAM1 (0.51) | HPGDLMNATSHRKDM4EMAPT | |
| Bromide SCHEMBL28458727 | 0.79 | ALDH1A1 (0.40) | LMNATSHRKDM4EMAPTALDH1A1 | |
| SCHEMBL6815303 | 0.78 | LMNA (0.58) | CA1CA2XDHCA12CA7 | |
| SCHEMBL2667058 | 0.78 | TSHR (0.56) | CA1CA2HPGDTSHRMAPT | |
| SCHEMBL15000832 | 0.77 | LOXL2 (0.59) | CA1CA2HPGDLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0963981-A1 | Biaryl heterocyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | Galderma Research & Development, S.N.C. (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0732328-B1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CIRD GALDERMA (FR) | 1998-09-09 | — | — | EP | disclosed |
| EP-0732328-A1 | Aromatic heterocyclic compounds, pharmaceutical and cosmetic compositions containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1996-09-18 | — | — | EP | disclosed |