Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 6/20 | 0.48 |
| ▸ | PDE1C | Q14123 | 6/20 | 0.48 |
| ▸ | PDE1A | P54750 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313452 | 0.83 | ALDH1A1 (0.56) | TYMSALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL4769071 | 0.76 | ALDH1A1 (0.60) | TYMSALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL8312892 | 0.74 | TYMS (0.58) | TYMSALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL8315901 | 0.74 | ALDH1A1 (0.54) | TYMSALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL26988574 | 0.73 | MAPT (0.49) | ALDH1A1MAPTKDM4EALOX15PDE1B | |
| SCHEMBL31560451 | 0.71 | MAPT (0.72) | ALDH1A1MAPTKDM4EALOX15PDE1B | |
| SCHEMBL4376098 | 0.70 | ALDH1A1 (0.57) | TYMSALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL17675021 | 0.70 | ALDH1A1 (0.57) | TYMSALDH1A1MAPTKDM4EALOX15 | |
| SCHEMBL8924914 | 0.70 | KDM4E (1.00) | ALDH1A1MAPTKDM4EALOX15MEN1 | |
| SCHEMBL4762572 | 0.70 | ALDH1A1 (0.63) | TYMSALDH1A1MAPTKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609328-B1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEM FAB (DE) | 1999-04-28 | — | — | EP | disclosed |
| US-5534515-A | Pyrrolopyridazines having gastrointestinal protective effects | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-07-09 | — | — | US | disclosed |
| WO-1993008190-A1 | PYRROLO-PYRIDAZINES WITH GASTRO-INTESTINAL PROTECTIVE ACTION | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1993-04-29 | — | — | WO | disclosed |